M00001635
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ISO 11350 1st Edition, May 15, 2012 Water quality - Determination of the genotoxicity of water and waste water - Salmonella/microsome fluctuation test (Ames fluctuation test)
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Availability date: 07/13/2021
Description / Abstract:
This International Standard specifies a method for the
determination of the genotoxic potential of water and waste water
using the bacterial strains Salmonella enterica subsp.
enterica serotype Typhimurium TA 98 and TA 100 in a
fluctuation assay. This combination of strains is able to measure
the genotoxicity of chemicals that induce point mutations (base
pair substitutions and frameshift mutations) in genes coding for
enzymes that are involved in the biosynthesis of the amino acid,
histidine.
NOTE 1 ISO 13829[8] applies for the measurement of
genotoxicity of samples containing DNA-crosslinking agents.
This method is applicable to:
— fresh water;
— waste water;
— aqueous extracts and leachates;
— eluates of sediments (fresh water);
— pore water;
— aqueous solutions of single substances or of chemical
mixtures;
— drinking water.
NOTE 2 When testing drinking water, extraction and
pre-concentration of water samples can prove necessary.